Celadrin is a relatively new development in the support of joint health but is rapidly
gaining an excellent reputation as more studies are completed. It is a complex
consisting of various fatty acids and is easily able to penetrate cell membranes, which
enhances membrane health and integrity. Celadrin appears to inhibit the production of
inflammatory compounds such as prostaglandins and research suggests a potential
benefit to those with arthritis. In one study sixty-four patients with chronic
osteoarthritis of the knee were given either Celadrin or a placebo and evaluated after
30 and 68 days. Results indicated that compared to placebo, Celadrin improves knee
range of motion and overall joint function. It was concluded that Celadrin may be an
alternative to the use of non-steroidal anti-inflammatory drugs for those with
Omega 3 fatty acids produce favourable effects in inflammatory conditions by
suppressing the production of inflammatory compounds produced by white blood cells.
Fish oils are thought to be especially beneficial in rheumatoid arthritis. In a double
blind, placebo controlled study patients using 1.8 grams of EPA per day reported less
morning stiffness and tender joints. In a more recent 1 year study, 2.6 grams per day of
omega 3 fatty acids from fish oil also resulted in significant improvement in symptoms
in a group of rheumatoid arthritis patients, reducing their need for drug therapy.
Oral AC-11 has been shown to decrease DNA damage and to increase DNA repair
capacity in human volunteers. Research has demonstrated that AC-11 inhibits the
nuclear transcription factor NF-kB, which is activated in arthritis and other
Antioxidants are especially important in any auto-immune diseases, which are often
inflammatory in nature, and rheumatoid arthritis is no exception. Antioxidants help to
control the inflammatory response. In fact some key antioxidants are consistently
found to be deficient in rheumatoid arthritis, including selenium and cysteine, key
components of an important antioxidant enzyme called glutathione peroxidase, which
is important in reducing levels of inflammatory compounds such as prostaglandins and
leukotrienes. A broad range of antioxidant nutrients is essential in the diet of
rheumatoid arthritis patients.
Ashwagandha (Withania somnifera)
Researchers have shown that ashwagandha exerts potent anti-inflammatory properties.
In addition, there is increasing interest in the potential for ashwagandha to be used in
auto-immune dysfunction; scientific investigation has demonstrated that ashwagandha
possesses immuno-modulatory capabilities, with both immune stimulating and immune
suppressive activity being associated with the herbs various active constituents.
Rheumatoid arthritis is as much an immune system disease as one of the joints, and
glucosamine supplementation is not likely to be as supportive of joint health as in
osteoarthritis. However, in combination with the other components of this protocol,
cartilage support in the form of glucosamine may be helpful. Glucosamine sulphate
provides raw material for the production of proteoglycans and glycosaminoglycans
(GAGs), important structural components of cartilage. Supplemental glucosamine
appears to stimulate collagen production by the chondrocytes as well as promoting
normal chondrocyte metabolism resulting in cartilage repair and reduced breakdown of
The active compounds in turmeric (curcuma longa) have powerful anti-inflammatory
effects and antioxidant activity, two properties that make it a very useful herb for those
with auto-immune conditions such as rheumatoid arthritis.
Rheumatoid Arthritis Summary
Nutrient/Herb Typical intake range
Celadrin1 500 – 2000mg per day
Fish oils2 2000 – 4000mg per day
AC-11 350 - 700mg per day
Antioxidant formula As per manufacturer’s directions
Ashwagandha (1.5% withanolides)3 300 – 900mg per day
Glucosamine (sulphate or hydrochloride) 1000 – 2000mg per day
Turmeric (95% curcuminoids)3, 4 300 – 900mg per day
Allergens (e.g. wheat, dairy)
Excessive animal proteins
Nuts and seeds
Green leafy vegetables
Vegetarian protein sources
Fibre (not wheat)
Identify potential allergens
Ideally follow a vegetarian diet
Consider digestive support (see ‘Digestive support’ section)
1. Possible interaction with Warfarin – concurrent use with medical supervision only.
2. Although interactions are rare, diabetics should be monitored if they intend to use glucosamine.
Allergy - the most common supplemental form is derived from shellfish
3. Do not use during pregnancy or lactation.
4. Do not use with Warfarin or anticoagulant medication. May reduce effectiveness of
immunosupressants – concurrent use under medical supervision only. Very high doses should not
be used concurrently with NSAID medication.