Gateway Health News

AMD (Age Related Macular Degeneration)

(Age Related Macular Degeneration)

Of the hundreds of carotenoids found in nature, lutein is perhaps one of the best
known, especially for it’s role in eye health. Lutein is abundant in the macula of the
eye, the very central portion of the retina responsible for sharp focus. In studies,
subjects with the lowest lutein intake have been found to be at the greater risk of
developing age related macular degeneration (AMD), a condition that results in blurred
vision or blindness. Lutein has been shown to filter the especially harmful blue and
purple light from the sun that is thought to be responsible for damaging the
photoreceptors of the macular.

The structure of astaxanthin is very close to that of lutein and zeaxanthin but has a
stronger antioxidant activity and UV-light protection effect. Due to the high
concentration of photoreceptor cells, the macular has the greatest potential for damage
by free radicals generated by ultra violet light. Studies have reported a significant
protective effect of astaxanthin in preventing damage to the visual system by absorbing
light energy and disarming free radicals. Studies suggest that the pigmentation and
potent antioxidant properties of astaxanthin make it especially valuable in protection
against age related macular degeneration and cataracts.

Bilberry Berries
Bilberry extracts have been used successfully in many clinical and experimental studies
for various eye dysfunctions. The active anthocyanoside (anthocyanidin) flavonoids in
bilberry extract have eye tonic properties, and scientific investigation points to
potential benefits in age-related macular degeneration, cataracts, retinopathy, and
glaucoma. Studies show bilberry extract improves circulation to the eyes, and enhances
oxygen and energy levels in eye tissue. Additionally, anthocyanosides stabilise collagen
(a major factor in maintaining eye integrity) and act as potent antioxidants (free
radicals are a major destructive element in eye degeneration).

Ginkgo biloba
Ginkgo biloba extract has been shown to increase circulation to the retina and improve
visual processes. The potent antioxidant compounds in ginkgo help to protect against
free radicals generated by ultra-violet light and are supportive of retinal integrity.

Zinc plays an important role in retinal function and studies support its use in slowing
down the rate of vision loss among those with AMD. Zinc deficiency is especially
common amongst the elderly population – those most at risk from age related vision
loss. In one study, subjects given zinc had significantly less vision loss than subjects in
the placebo group. Studies suggest that zinc may be most relevant in ‘dry’ AMD, as
opposed to ‘wet’ AMD, where study results have been mixed.

AMD Summary
Nutrient/Herb Typical intake range
Lutein 1 – 15mg per day
Astaxanthin 1 – 5mg per day
Bilberry Berries (25% anthocyanosides)1 60 – 180mg per day
Ginkgo biloba extract
(24% ginkgoflavoglycosides)2
60 – 180mg per day
Zinc3 15 – 30mg per day
Antioxidant formula As per manufacturer’s instructions

Fried foods
Burnt foods
Trans/hydrogenated fats
Pesticide exposure
Artificial additives/preservatives

Yellow/orange vegetables
Fruit (especially berries)
Nuts and seeds
Organic foods
Whole grains

Lifestyle Factors

Stop Smoking (smoking more than doubles risk of developing AMD)
Limit exposure to UV light (wear sunglasses in bright sunlight)
Limit exposure to environmental toxins and other sources of free radicals

1. Do not use during pregnancy or lactation. Concurrent use with Warfarin, anti-platelet
medication, insulin and oral hypoglycaemic medication under medical supervision only.
2. Do not use during pregnancy or lactation. May decrease the action of Warfarin. Concurrent use
with insulin and oral hypoglycaemic medication under medical supervision only. Do not use with
MAOI anti-depressants.
3. May cause nausea on an empty stomach. High doses (>100mg per day) may suppress the immune
system. Ensure sufficient copper and iron intake with zinc supplementation.